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GLP-1RAs, such as exendin-4 and liraglutide, can reduce neuroinflammation caused by microglia by encouraging a conversion from the pro-inflammatory M1 subtype towards the anti-inflammatory M2 phenotype
According to this definition, a diagnosis of MetS is made when 3 of the following 5 risk factors are present: enlarged waist circumference with population and country-specific criteria
Safety only comes from structure, not from the peptide alone
Thus, it is attractive to hypothesize that GLP-1 signalling could enhance flux through the glycolytic pathway to generate metabolic stimulus-secretion factors
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