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4.3.3 The MMPM+HFD + ADF model rats exhibit notable changes in hippocampal An increasing body of evidence suggests that the brain serves as a central regulator of fatigue (Seguro et al., 2022)

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Its extended half-life allows for sustained investigation into the regulation of food intake and body weight maintenance in obese rodent models

They explain why hitting multiple pathways simultaneously might be more beneficial for sustained weight and fat loss than single-pathway medications

To this extent, previous reports have shown that the control of MZB localization in the spleen depends on signals delivered by integrins and chemokines such as ICAM-1 and VCAM-1 16,53