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Large meals or high-fat meals exacerbate this, leading to nausea and discomfort
doi:10.3389/fnut.2025.1659500 Abdallah H, Khalil M, Farella I, et al
In comparison, the average cup of coffee contains 95 mg of caffeine, so this isn't considered a large amount unless you're especially sensitive to the effects of caffeine
Timing Follow-up Marker Blood pressure and resting heart rate Why it matters Adds cardiovascular context during weight loss and retatrutide-related heart-rate monitoring
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