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Procyanidin oligomers and polymers reach the large intestine where they are subjected to microbial metabolism yielding e.g., phenylvalerolactones (see section 6.1 Pre-systemic metabolism: role of gut microbiota)
& Ismail, K
doi: 10.1016/S0092-8674(05)80081-9 53 GranstrmM.EricssonA.StrandvikB.WretlindB.PavlovskisO
For example: Diet and exercise are a must
These insignificant changes may be attributed to bias caused by the small sample size of the included studies
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