When stratified by administration route, the average percentage reductions were: Intramuscular (IM): 48.3% Sublingual: 30.7% Oral: 30.3% These results suggest that IM administration leads the most pronounced homocysteine reduction, however, sublingual and oral routes also demonstrate clinically relevant effects
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This is why all B12 treatments experts advise not to retest B12 levels after treatment has begun as they are not a reliable guide to whether treatment is being effective
MIC B12 injections are commonly used alongside GLP-1 receptor agonists like semaglutide or tirzepatide
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An intramuscular (IM) injection delivers vitamin B12 directly into a muscle, usually in the upper arm, thigh, or upper buttocks