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Concerning signs that require medical attention include: Spreading redness larger than a few inches Red streaks Severe or worsening pain Fever or chills Hives away from the site Facial or throat swelling Any breathing difficulty When symptoms worsen rather than improve, document the site with a photo and contact your clinician promptly so they can assess for infection or a true allergic response

Another large study showed that using GLP-1s may help prevent immune-related diseases in people with diabetes or obesity People with diabetes who took GLP-1 drugs had a lower chance of developing rheumatoid arthritis, gout, and osteoarthritis compared to people on other diabetes medications

Neill JC, Barnes S, Cook S, Grayson B, Idris N, et al

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Recently, microphthalmic transcription factor, tyrosinase, and melano-A immunostains have been used to highlight melanocytes