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GLP-1 therapy helps stop what we call foot chatterthose constant trips to the pantry or fridge
& Backhed, F
It is not added because it makes the drug work better at the receptor level
A post hoc analysis of patients with T2DM receiving dulaglutide or tirzepatide showed improved biomarkers of MASLD with levels of cytokeratin-18 M30 fragment and procollagen III significantly reduced in patients treated with higher doses of tirzepatide.15 In a retrospective, propensity score matched study from veterans affairs (VA) hospitals in patients with MASLD, treatment with GLP-1RA compared with DPP-4 inhibitors reduced progression to cirrhosis (HR 0.86, 95% CI 0.75 to 0.98), but there was no protective effect in those who had already developed cirrhosis.16 This suggests the timing of treatment needs to be considered, and we also need studies on changes in liver histology with these agents, as this VA trial used clinical and biochemical diagnoses
Uptake of sodium-glucose cotransporter-2 inhibitors in hospitalized patients with heart failure: insights from the Veterans Affairs Healthcare system
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