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All of those factors help slow kidney disease progression, so I think GLP-1 receptor agonists are a great addition to our existing armamentarium. Where Obesity, CKD, and T2D Intersect with Semaglutide: The FLOW Trial The approval for semaglutide for patients with T2D and CKD was based on data from FLOW, a phase 3b, multinational, parallel-group, double-blind, randomized, placebo-controlled trial investigating the effects of 1.0 mg once weekly semaglutide, a once-weekly GLP-1RA, on kidney outcomes in participants with CKD and T2D

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According to a case report published in the Journal of Investigative Medicine in October 2021, a 52-year-old female taking semaglutide reported experiencing severe gastric pain, accompanied by fullness, bloating, and vomiting within one month of starting weekly injections

Because the autonomic nervous system regulates digestive motility, POTS patients frequently swing between extremes: rapid gastric emptying (causing diarrhea and malabsorption) or delayed gastric emptying (gastroparesis, causing severe nausea and early satiety)

SCFA: mechanisms and functional importance in the gut