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Despite this initial disappointment, Soleno Therapeutics initiated an open-label follow-up trial, C602, to see how the drug performed over a longer period

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These findings indicate that: Members in Omadas Enhanced GLP-1 Care Track showed higher average medication persistence rates through 24 weeks compared to other real-world evidence Those who persisted saw an average of 11% weight loss with semaglutide and 13% with tirzepatide, outcomes similar to what has been shown in clinical trials Providing the right kind of support to enable people to persist with their GLP-1 medication use long enough to see benefits can help them achieve clinical trial-level weight loss, setting the stage for cardiometabolic disease risk reduction

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After 10 years of treatment, the incidence of MALE was significantly lower in the GLP-1RAs group than in the non-GLP-1RAs group (Celsa et al., 2025)