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Comorbidities included smoking, hypertension, and type 2 diabetes mellitus

Tan B, Pan XH, Chew HSJ, et al

Choose plain, unsweetened varieties to avoid added sugar that could interfere with blood sugar control

Semaglutide's known adverse effects include gastrointestinal symptoms (nausea, vomiting, constipation), pancreatitis risk, and thyroid concernsside effects that could theoretically be complicated by naltrexone's CNS effects