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Nat Cell Biol 15:1727 Gadde S, Heald R (2004) Mechanisms and molecules of the mitotic spindle

12.2 Pharmacodynamics The use of DDAVP Nasal Spray in patients with central diabetes insipidus reduces urinary output, increases urine osmolality, and decreases plasma osmolality

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As noted, vigorous shaking creates foam and can lead to protein denaturation or aggregation