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DPP-4 inhibitors which increase levels of GLP-1, a hormone that helps reduce blood sugar levels have been approved for treatment of type 2 diabetes since 2006

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Accordingly, Glutathione-S Transferase p1 (GSTP1), which we recently found to be an autocrine stimulator of mutated KRAS signaling, is predicted to be an alternative target for chemoprevention of pancreatic cancer

For Blue Cross, losses are likely to continue into this year, despite the insurer eliminating jobs, deploying computer algorithms to target doctors it believes are overcharging, restricting coverage of GLP-1 drugs for weight loss, and pushing back against health care providers seeking higher reimbursement rates