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Thus, NRF2 prevents ferroptosis by inducing the expression of genes involved in both GPX4-dependent and GPX4-independent pathways

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France Researchers study its role in melanocortin receptor signaling, melanin production, skin pigmentation, appetite regulation, and sexual behavior pathways

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SARS-CoV-2 infection generates massive ROS production and the excessive oxidative damage is responsible for cytokine storm, undermined immunity, tissue damage and severe lung disease causing ARDS and death (Silvagno et al., 2020)