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Nature 540 , 544551 (2016)

Once you have reached your target weight, you do not need to stay at the dose that got you there

This sustained action leads to a far stronger effect on appetite suppression and blood sugar control than what the body can achieve naturally, which is why these medications are highly effective treatments for type 2 diabetes and obesity

Sources: Raun K, et al

However, unlike supplements like creatine or caffeine, its benefits are often indirect and may take weeks or months to appear

But the underlying rationale isn't invented, which is a meaningful distinction from products that make claims without any mechanistic basis at all