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An already-elevated baseline IGF-1 is a reason not to push the axis higher, and because GH antagonizes insulin, glucose handling deserves attention in patients with diabetes or prediabetes

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PMC 2026

Author contributions Conceived and designed the experiments: ZY, LL, YZ, and PC

Supporting this, ERK1 and ERK2 are overexpressed in leiomyoma as compared to the normal myometrium (Yu et al., 2008)