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Cu(II) is held in a square-planar coordination sphere by the N-terminal amine, the deprotonated glycyl amide nitrogen and the histidine imidazole, at a stability constant (log K approximately 16.4) close to that of the copper transport site on human serum albumin

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Nonetheless, because autism is influenced by multiple interacting genetic and environmental factors that are case-specific and inherent limitations in post-mortem brain, these observations will require confirmation in subsequent studies

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