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The results revealed that the duration of contraceptive use was significantly negatively correlated with vitamin E levels (r = 0.67, p = 0.001) and GPX activity (r = 0.56, p = 0.004), indicating that longer use of oral contraceptives is associated with a greater decrease in these antioxidants

To demonstrate the role of GSH in chemotherapy resistance, we analyzed transcriptomic data from chemotherapy patient samples in the GEO database and collected post-chemotherapy samples from patients who underwent neoadjuvant chemotherapy, assessing the expression levels of GSH and GSH synthesis-related antioxidant enzymes

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p53 can reduce the expression levels of SLC7A11 by directly inhibiting its transcription, which reduces cysteine uptake and GSH synthesis, thereby impairing GPX4 activity and increasing cellular sensitivity to ferroptosis (73,74)