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Kat6a +/ mice were intercrossed to obtain Kat6a +/+ , Kat6a +/ , and Kat6a / E12.5 embryos

46 Adverse Effects and Tolerability of GLP-1RAs in Clinical Practice Although the cardiovascular benefits of GLP-1RAs are significant, their use is commonly associated with well-characterised adverse effects that can affect tolerability and long-term medication adherence, as detailed below

Calcitriol primarily functions by binding to the vitamin D receptor (VDR), a ligand-activated transcription factor

it was observed that LOX expression levels were increased at both the mRNA and protein level, and this may be prevented by inhibitors of the TGF- cascade (94)

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