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Side-effects range from mild (nausea, injection-site discomfort) to serious and even life-threatening (allergic reactions, liver injury, systemic inflammatory response, endotoxin-related events)
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To improve the BBB permeability of cytotoxic T-lymphocyte associated antigen 4 (a-CTLA-4) and programmed cell death-1 (a-PD-1) for immunotherapy of brain glioma, Ljubimova and co-workers described a nanoscale immunoconjugate system
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