2,3 REDEFINE 1 was a 68-week, double-blind, randomized, placebo- and active-controlled phase 3 trial that evaluated the efficacy and safety of once-weekly CagriSema versus cagrilintide 2.4 mg monotherapy, semaglutide 2.4 mg monotherapy, and placebo, all in combination with lifestyle intervention in 3,417 adults with obesity or overweight with one or more obesity-related complications and without type 2 diabetes
Mol Genet Genomics 291, 16391646 (2016)
A lipidomic signature may be highly informative in obesity-related or diabetic hypertrophy but less central in pressure overload without metabolic syndrome
These include diabetes, cancer, and rheumatoid arthritis
They also lost less weight and survived better than their control littermates (Kumar et al., 2016)
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