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It stands to reason that if a potentially epileptogenic ICI is employed in a seizure-vulnerable patient population, e.g., GBM, this may indirectly encourage tumor progression secondary to increased epileptiform activity and paradoxically result in decreased therapeutic efficacy

GLP-1s are thought to cause higher muscle loss (2539%) than non-pharmacological methods of weight loss, such as diet and exercise (10-30%) 29

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The two mechanisms are complementary: tirzepatide stops excess eating before it happens, while L-carnitine optimizes how your body processes fat already mobilized during weight loss

People without diabetes lost an average of 20% of their body weight on average over about 16 months, which is a significant amount for a medication

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