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PMID 10679944

5.2 Angiogenesis and hypoxia Tumor growth relies on angiogenesis, and ID regulates this process through the HIF-1 pathway (108)

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The copper ion binds to the peptide through a square-planar pyramid configuration, creating an extraordinarily stable complex with a binding affinity (pK = 16.44) approximately 10 million times higher than other tripeptides

Broader adoption requires careful evaluation of safety, cost, and evidence for less-established indications