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People with a severe deficiency or absorption problems can feel the effect wear off sooner

Although raised homocysteine levels might be partly due to a poor vitamin B 12 status, the latter was not related to risk of dementia or Alzheimer's disease in this study (73)

National Institutes of Health, Office of Dietary Supplements

Not well supported: High-quality, reproducible human trials demonstrating meaningful improvement in tendon/ligament healing time, re-injury rates, or function with these specific compoundsespecially as used in the wild (variable dosing, variable sourcing, variable diagnosis)

This is not ordinary tiredness but a profound lack of energy that does not improve with rest