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Multiple clinical trials show improvements in wrinkle depth, skin elasticity, and UV-induced damage after 612 weeks of supplementation (Tominaga et al., 2012, Acta Biochimica Polonica )

The authors checked a subset of 909 participants against their medical records and found that participants tended to overstate their weight loss (5.79% measured vs 11.8% self-reported, median BMI change)

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Its part of effective treatment

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The trade-off is co-stimulation of cortisol and prolactin that ipamorelin largely avoids