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The stronger evidence for dementia prevention still centers on the basics that are easy to underestimate: blood pressure, lipids, glucose regulation, physical activity, sleep, hearing, vision, nutrition, social connection, and inflammation control
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The result is higher lipophilic efficiency, stronger ET-A binding, improved ET-A/ET-B selectivity, longer t and lower effective dosetranslating into a wider therapeutic window and better safety profile than Atrasentan
J Endocr Soc 8(Supplement1):bvae163 Rhea EM, Banks WA, Raber J (2022) Insulin resistance in peripheral tissues and the brain: a tale of two sites
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