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Clinical research suggests that tirzepatide may produce greater average weight loss for some individuals, likely because it activates two metabolic hormone pathways instead of one
& Donnelly, J
Variability-accommodating pharmacodynamics (time-integrated effects): When pharmacodynamic effects integrate over time and depend on the area under the curve (AUC) or sustained receptor occupancy rather than peak concentration, transient fluctuations in plasma concentration have limited clinical consequences
User reports for Achilles conditions consistently describe rapid initial response
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That being said, there are other aspects of the medications that seem to have other effects that are independent of weight loss, independent of blood glucose lowering, that I do not think we still fully have an answer to, he said
